LS 3443-0

Brief

This course will focus on the recent advances in our understanding of the clinical features and pathogenesis of a wide range of neurodegenerative diseases, including Alzheimer’s disease, Parkinson's disease and parkinsonisms, ataxias, motor neuron diseases, and polyglutamine diseases. Students will analyze research reports in which a range of proposed cellular processes that may represent the underlying pathogenic mechanisms in these diseases. Topics li<x>nk to the proposed cellular processes will include accumulation of aberrant proteins, protein misfolding, protofibril formation, ubiquitin-proteosomal pathway, autophagy, ER stress, axonal and dendritic transport, excitotoxic insult, and mitochondrial dysfunction. The course will especially emphasis and explore genetic contributions to neurodegenerative disease, as identification of genetic mutations for familial neurodegenerative diseases has been a major driving force in neurodegenerative research.

Description

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Timetable

Remarks

Restrictions

Compulsory

Elective

Cross Discipline

First Specialization

Second Specialization